Acute Respiratory Distress Syndrome (ARDS) Market Key Company

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Acute Respiratory Distress Syndrome (ARDS) Market Insights, Epidemiology and Market Forecast 2030 report delivers an in-depth understanding of the Acute Respiratory Distress Syndrome (ARDS), historical and forecasted epidemiology as well as the Acute Respiratory Distress Syndrome (ARDS) market trends in the United States, EU5 (Germany, France, Italy, and United Kingdom) and Japan.

The Acute Respiratory Distress Syndrome (ARDS) market report provides current treatment practices, emerging drugs, and market share of the individual therapies, current and forecasted 7MM Acute Respiratory Distress Syndrome (ARDS) market size from 2017 to 2030. The report also covers current Acute Respiratory Distress Syndrome (ARDS) treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market.

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Geography Covered

– The United States

– EU5 (Germany, France, Italy, Spain, and the United Kingdom)

– Japan

Study Period: 2017-2030

Acute Respiratory Distress Syndrome (ARDS) Disease Understanding and Treatment Algorithm

Acute Respiratory Distress Syndrome (ARDS) Overview

Acute respiratory distress syndrome (ARDS) is a rapidly progressive disease occurring in critically ill patients. The main complication in ARDS is that fluid leaks into the lungs, making breathing difficult or impossible. Acute lung injury (ALI) is a common condition characterized by acute severe hypoxia that is not due to left atrial hypertension. The term ALI encompasses a continuum of clinical and radiographic changes that affect the lungs with the acute respiratory distress syndrome (ARDS) representing the more severe end of this continuum. Despite advances in the understanding of the pathophysiology and management of ALI, it is still associated with high mortality.

The causes of ARDS are divided into two categories: direct or indirect injuries to the lung. Some of the direct injuries to the lung include pneumonia, aspiration, trauma, and others whereas the indirect injuries to the lung include inflammation of the pancreas, severe infection (also known as sepsis), blood transfusions, burns, and medication reactions. The few symptoms of ARDS are shortness of breath, cough, and fever. In some cases, those with ARDS also have fast heart rates and rapid breathing. Occasionally, patients of ARDS experience chest pain, especially during inhalation. Some patients also experience bluish coloring of nails and lips due to the severely decreased oxygen levels in the blood. There are several risks factors that may escalate the risk for ARDS; this involves obesity, alcohol abuse, chemotherapy, low-protein in blood.

A novel strain of coronavirus emerged in December 2019, which was termed as COVID-19 by the World Health Organization (WHO). Coronaviruses belong to a family of viruses that range from the common cold to MERS coronavirus, which is Middle East Respiratory Syndrome and Severe acute respiratory syndrome (SARS) coronavirus. The clinical data of COVID-19 severely infected patients suggest that radiologic evidence of lung edema— a manifestation of ALI and may progress to hypoxemia and potentially ARDS—is common. The occurrence and severity of ALI are a major determining factor of the prognosis of patients with COVID-19 infection. About 30% of patients with COVID-19 infection in the ICU developed severe lung edema, dyspnea, hypoxemia, or even ARDS. COVID-19 patients diagnosed with ARDS have a poor prognosis and high mortality.

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Acute Respiratory Distress Syndrome (ARDS) Diagnosis

The diagnosis of Acute Respiratory Distress Syndrome (ARDS) is based on the identification of characteristic symptoms, a detailed patient history, a thorough clinical evaluation and a variety of specialized tests.

ARDS is characterized by an acute, diffuse, inflammatory lung injury, leading to increased alveolar-capillary permeability, increased lung weight, and loss of aerated lung tissue. Clinically, this establishes as hypoxemia, with bilateral opacities on chest radiography, associated with reduced lung compliance and increased venous admixture and physiological dead space. Morphologically, diffuse alveolar damage is observed in the acute phase of ARDS.

Acute Respiratory Distress Syndrome (ARDS) Treatment

The Acute Respiratory Distress Syndrome (ARDS), a life-threatening condition, was described as a form of respiratory failure that closely resembled respiratory distress syndrome in infants. This can be caused by a variety of pulmonary (such as pneumonia, aspiration) or non-pulmonary (like sepsis, pancreatitis, and trauma) abuses, leading to the development of non-hydrostatic pulmonary edema. The treatment of ARDS involves general supportive measures, ventilator strategies, and appropriate treatment of the underlying condition. Besides general supportive measures, pharmacological interventions are commonly considered throughout ARDS. Although research involving the investigation of drug candidates is being carried out for over a decade, only a few pharmacological therapies have emerged for ARDS.

Despite decades of research, treatment options for ARDS are restricted. Supportive care with mechanical ventilation remains the mainstay of management. There are relatively few treatments available for ARDS. Other treatment options, which the patients with ARDS are generally subjected include supplemental oxygen, prone positioning, use of paralytics, fluid management, and a technique called positive end-expiratory pressure (PEEP) to help push the fluid out of air sacs. These are combined with continuing treatment of the original illness or injury. Because people with ARDS are less able to fight lung infections, they may develop bacterial pneumonia during the illness. Antibiotics are given to fight infection. Also, supportive treatment, such as intravenous fluid or food, may be needed.

It covers the details of conventional and current medical therapies available in the Acute Respiratory Distress Syndrome (ARDS) market for the treatment of the various types of Acute Respiratory Distress Syndrome (ARDS). It also provides the treatment guidelines and algorithms of the United States and Europe. Acute Respiratory Distress Syndrome (ARDS) market report gives a thorough understanding of Acute Respiratory Distress Syndrome (ARDS) by including details such as disease definition, causes, risk factors, pathogenesis, and diagnosis.

Acute Respiratory Distress Syndrome (ARDS) Epidemiology

The disease epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by Total Incident Population of ARDS, Severity-specific Incidence of ARDS, and Incidence of ARDS by Risk Factors scenario of Acute Respiratory Distress Syndrome (ARDS) in the 7MM market covering the United States, EU5 countries (Germany, France, Italy, Spain, and United Kingdom) and Japan from 2017 to 2030.

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Key Findings

This section provides glimpses of the Acute Respiratory Distress Syndrome (ARDS) epidemiology in the 7MM.

– In the 7MM, the total incident population of ARDS is estimated to be 799,872, in 2017.

– Generally, the highest number of incident cases were assessed for ARDS due to Pneumonia, in all the 7MM countries, except the United Kingdom, in which Sepsis was the primary risk factor for ARDS.

– Due to occurrence of COVID-19, there is a sudden increase in the cases of ARDS in the US, from 495,655 in 2017, to 550,371 in 2020.

Country Wise-Acute Respiratory Distress Syndrome (ARDS) Epidemiology

The epidemiology segment also provides the Acute Respiratory Distress Syndrome (ARDS) epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom) and Japan.

Acute Respiratory Distress Syndrome (ARDS) Drug Chapters

The drug chapter segment of the Acute Respiratory Distress Syndrome (ARDS) report encloses the detailed analysis of Acute Respiratory Distress Syndrome (ARDS) marketed drugs and mid- and late-stage pipeline drugs. It also helps to understand the Acute Respiratory Distress Syndrome (ARDS) clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details of each included drug and the latest news and press releases.

Acute Respiratory Distress Syndrome (ARDS) Emerging Drugs

Traumakine: Faron Pharmaceuticals

Interferon-beta-1a also known as Traumakine; FP-1201-lyo; MR11A8; FP-1201; Recombinant Human IFN Beta-1a—is under development by Faron Pharmaceuticals as its lead drug candidate. It is a lyophilized powder form of recombinant human IFN beta-1a reconstituted in water for injection. It is administered intravenously, and targets the Interferon-beta receptor 1, activating its action. In January 2018, Faron Pharmaceuticals received Fast Track designation from the US Food and Drug Administration (FDA) for Traumakine, for the treatment of ARDS. The drug is in phase III (CALIBER Global Study) clinical developmental trial for the patients with ARDS.

Products detail in the report.

BIO-11006: BioMarck Pharmaceuticals

BioMarck Pharmaceuticals is developing its lead compound BIO-11006 under the Phase II stage of development for the treatment of Adult Respiratory Distress Syndrome (ARDS). Biomarck’s BIO-11006 is a novel, highly soluble, patented, 10 amino acid peptides. It acts as a MARCKS (Myristoylated alanine-rich C kinase substrate) protein inhibitor and is being developed to specifically target the MARCKS protein to inhibit cancer cell division and movement. Furthermore, it is a water-soluble, stable aerosolized anti-MARCKS peptide inhalation solution that involves aerosolized delivery of either the active drug or placebo by the “Aeroneb Pro nebulizer”

Products detail in the report.

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MultiStem: Athersys

MultiStem; also known as AMI MultiStem; HLCM 051 and PF-05285401—is a patented regenerative product which can promote tissue repair and healing in a variety of ways, such as through the production of multiple therapeutic factors produced in response to signals of inflammation and tissue damage and restore immune system balance. MultiStem is under development by Athersys and is currently in the Phase II stage for the treatment of Acute Respiratory Distress Syndrome. Currently, the US FDA granted Fast Track designation to Athersys for its clinical program evaluating MultiStem cell therapy for the treatment of ARDS.

Products detail in the report:

Solnatide: Apeptico Forschung und Entwicklung GmbH

Solnatide (AP301; synonym to TNF-derived TIP-peptide) under development by Apeptico Forschung und Entwicklung GmbH is a synthetic molecule whose structure bases on the lectin-like domain of the Human Tumor Necrosis Factor a. The AP301 peptide is water-soluble and can be administered into the lung by oral inhalation. The drug is conducting phase II clinical developmental trial in patients with ARDS.

Apart from these, Lenzilumab, tocilizumab (TCZ), aviptadil, ruxolitinib, tradipitant, and remestemcel-L, are the other pipeline therapies, which are expected to enter the market in the forecasted period that will be targeting the COVID-19 associated ARDS cases.

Lenzilumab: Humanigen, Inc.

Lenzilumab is an anti-human granulocyte macrophage-colony stimulating factor (GM-CSF) monoclonal antibody drug candidate that is being evaluated in an ongoing Phase III trial and was selected by the National Institutes of Health for its COVID-19 Big Effect Trial.

Products detail in the report:

Actemra/RoActemra (Tocilizumab): Roche Pharma AG

Actemra/RoActemra (Tocilizumab) is another investigational molecule that is in phase III stage of development for SARS-CoV-2 infection and evidence of systemic inflammation. From some studies, it has been observed that Tocilizumab can be a suitable and effective therapy for severe cases of COVID-19 associated with acute respiratory distress syndrome.

List to be continued in the report:

Acute Respiratory Distress Syndrome (ARDS) Market Outlook

Despite recent advances in critical care, the mortality due to ARDS varies from 35% to 45% in various studies. The mortality has been reported to be associated with organ failure, sepsis, age, and associated comorbid illness. The treatment of ARDS involves general supportive measures, ventilator strategies, and appropriate treatment of the underlying condition. Besides general supportive measures, pharmacological interventions are commonly considered throughout ARDS. Although research involving the investigation of drug candidates is being carried out for over a decade, only a few pharmacological therapies have emerged for ARDS. In the off-label treatment options, STATIN therapy, NMBAs, and glucocorticosteroids are recommended because there is no approved therapy for this indication yet.

The Acute Respiratory Distress Syndrome (ARDS) market outlook of the report helps to build a detailed comprehension of the historic, current, and forecasted Acute Respiratory Distress Syndrome (ARDS) market trends by analyzing the impact of current therapies on the market, unmet needs, drivers and barriers, and demand of better technology.

This segment gives a thorough detail of Acute Respiratory Distress Syndrome (ARDS) market trend of each late-stage pipeline therapy by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria’s, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated market data are presented with relevant tables and graphs to give a clear view of the market at first sight.

Acute Respiratory Distress Syndrome (ARDS) 7MM market is expected to change in the study period 2017-2030.

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Key Findings:

This section includes a glimpse of the Acute Respiratory Distress Syndrome (ARDS) 7MM market.

– According to DelveInsight estimates, the United States accounts for the largest market size of Acute Respiratory Distress Syndrome (ARDS), in comparison to Japan and EU5 (Germany, Italy, France, UK and Spain).

– The market size of Acute Respiratory Distress Syndrome (ARDS) in the seven major markets was 917.81 Million in 2017.

– Expected launch of potential therapies may increase the market size in the coming years, assisted by an increase in the incident population of ARDS and awareness of the disease.

The United States Market Outlook

This section provides the total Acute Respiratory Distress Syndrome (ARDS) market size and market size by therapies in the United States.

EU-5 Market Outlook

The total Acute Respiratory Distress Syndrome (ARDS) market size and market size by therapies in Germany, France, Italy, Spain, and the United Kingdom are provided in this section.

Japan Market Outlook

The total Acute Respiratory Distress Syndrome (ARDS) market size and market size by therapies in Japan are provided.

Acute Respiratory Distress Syndrome (ARDS) Drugs Uptake

This section focusses on the rate of uptake of the potential drugs recently launched in the Acute Respiratory Distress Syndrome (ARDS) market or expected to get launched in the market during the study period 2017–2030. The analysis covers Acute Respiratory Distress Syndrome (ARDS) market uptake by drugs; patient uptake by therapies; and sales of each drug.

This helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new drugs and allow the comparison of the drugs based on market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.

Acute Respiratory Distress Syndrome (ARDS) Development Activities

The report provides insights into different therapeutic candidates in phase II, and phase III stage. It also analyzes key players involved in developing targeted therapeutics.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing and patent details for Acute Respiratory Distress Syndrome (ARDS) emerging therapies.

Competitive Intelligence Analysis

We perform competitive and market intelligence analysis of the Acute Respiratory Distress Syndrome (ARDS) market by using various competitive intelligence tools that include–SWOT analysis, PESTLE analysis, Porter’s five forces, BCG Matrix, Market entry strategies, etc. The inclusion of the analysis entirely depends upon the data availability.

Scope of the Report

– The report covers the descriptive overview of Acute Respiratory Distress Syndrome (ARDS), explaining its causes, signs and symptoms, pathogenesis and currently available therapies.

– Comprehensive insight has been provided into the Acute Respiratory Distress Syndrome (ARDS) epidemiology and treatment.

– Additionally, an all-inclusive account of both the current and emerging therapies for Acute Respiratory Distress Syndrome (ARDS) are provided, along with the assessment of new therapies, which will have an impact on the current treatment landscape.

– A detailed review of Acute Respiratory Distress Syndrome (ARDS) market; historical and forecasted is included in the report, covering the 7MM drug outreach.

– The report provides an edge while developing business strategies, by understanding trends shaping and driving the 7MM Acute Respiratory Distress Syndrome (ARDS) market.

Report Highlights

– Total Incident Population of Acute Respiratory Distress Syndrome (ARDS) in the 7MM is anticipated to rise in the forecasted period (2017–2030).

– The market for ARDS in the 7MM is projected to rise during the study period (2017–2030).

– Dynamic research and developmental activity with 60+ companies in the pipeline at different stages.

– In the coming years, Acute Respiratory Distress Syndrome (ARDS) market is set to change due to the rising awareness of the disease, and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market.

– The companies and academics are working to assess challenges and seek opportunities that could influence Acute Respiratory Distress Syndrome (ARDS) R&D. The therapies under development are focused on novel approaches to treat/improve the disease condition.

– Major players are involved in developing therapies for Acute Respiratory Distress Syndrome (ARDS). Launch of emerging therapies will significantly impact the Acute Respiratory Distress Syndrome (ARDS) market.

– Our in-depth analysis of the pipeline assets across different stages of development (phase III and phase II), different emerging trends and comparative analysis of pipeline products with detailed clinical profiles, key cross-competition, launch date along with product development activities will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the research and development activities.

Acute Respiratory Distress Syndrome (ARDS) Report Insights

– Patient Population

– Therapeutic Approaches

– Acute Respiratory Distress Syndrome (ARDS) Pipeline Analysis

– Acute Respiratory Distress Syndrome (ARDS) Market Size and Trends

– Market Opportunities

– Impact of upcoming Therapies

Acute Respiratory Distress Syndrome (ARDS) Report Key Strengths

– Eleven Years Forecast

– 7MM Coverage

– Acute Respiratory Distress Syndrome (ARDS) Epidemiology Segmentation

– Key Cross Competition

– Highly Analyzed Market

– Drugs Uptake

Acute Respiratory Distress Syndrome (ARDS) Report Assessment

– Current Treatment Practices

– Unmet Needs

– Pipeline Product Profiles

– Market Attractiveness

– Market Drivers and Barriers

Key Questions:

Market Insights:

– What was the Acute Respiratory Distress Syndrome (ARDS) market share (%) distribution in 2017 and how it would look like in 2030?

– What would be the Acute Respiratory Distress Syndrome (ARDS) total market size as well as market size by therapies across the 7MM during the forecast period (2020–2030)?

– What are the key findings pertaining to the market across the 7MM and which country will have the largest Acute Respiratory Distress Syndrome (ARDS) market size during the forecast period (2020–2030)?

– At what CAGR, the Acute Respiratory Distress Syndrome (ARDS) market is expected to grow at the 7MM level during the forecast period (2020–2030)?

– What would be the Acute Respiratory Distress Syndrome (ARDS) market outlook across the 7MM during the forecast period (2020–2030)?

– What would be the Acute Respiratory Distress Syndrome (ARDS) market growth till 2030, and what will be the resultant market size in the year 2030?

– How would the market drivers, barriers and future opportunities affect the market dynamics and subsequent analysis of the associated trends?

Epidemiology Insights:

– What is the disease risk, burden and unmet needs of Acute Respiratory Distress Syndrome (ARDS)?

– What is the historical Acute Respiratory Distress Syndrome (ARDS) patient pool in the United States, EU5 (Germany, France, Italy, Spain, and the UK) and Japan?

– What would be the forecasted patient pool of Acute Respiratory Distress Syndrome (ARDS) at the 7MM level?

– What will be the growth opportunities across the 7MM for the patient population pertaining to ARDS?

– Out of the countries mentioned above, which country would have the highest prevalent population of Acute Respiratory Distress Syndrome (ARDS) during the forecast period (2020-2030)?

– At what CAGR the population is expected to grow across the 7MM during the forecast period (2020-2030)?

Current Treatment Scenario, Marketed Drugs and Emerging Therapies:

– What are the current options for the treatment of Acute Respiratory Distress Syndrome (ARDS) along with the approved therapy?

– What are the current treatment guidelines for the treatment of Acute Respiratory Distress Syndrome (ARDS) in the US and Europe?

– What are the Acute Respiratory Distress Syndrome (ARDS) marketed drugs and their MOA, regulatory milestones, product development activities, advantages, disadvantages, safety and efficacy, etc.?

– How many companies are developing therapies for the treatment of Acute Respiratory Distress Syndrome (ARDS)?

– How many therapies are developed by each company for the treatment of Acute Respiratory Distress Syndrome (ARDS)?

– How many emerging therapies are in the mid-stage and late-stage of development for the treatment of Acute Respiratory Distress Syndrome (ARDS)?

– What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Acute Respiratory Distress Syndrome (ARDS) therapies?

– What are the recent novel therapies, targets, mechanisms of action and technologies developed to overcome the limitation of existing therapies?

– What are the clinical studies going on for Acute Respiratory Distress Syndrome (ARDS) and their status?

– What are the key designations that have been granted for the emerging therapies for Acute Respiratory Distress Syndrome (ARDS)?

– What are the 7MM historical and forecasted market of Acute Respiratory Distress Syndrome (ARDS)?

Reasons to buy

– The report will help in developing business strategies by understanding trends shaping and driving the Acute Respiratory Distress Syndrome (ARDS).

– To understand the future market competition in the ARDS market and Insightful review of the key market drivers and barriers.

– Organize sales and marketing efforts by identifying the best opportunities for Acute Respiratory Distress Syndrome (ARDS) in the US, Europe (Germany, Spain, Italy, France, and the United Kingdom) and Japan.

– Identification of strong upcoming players in the market will help in devising strategies that will help in getting ahead of competitors.

– Organize sales and marketing efforts by identifying the best opportunities for Acute Respiratory Distress Syndrome (ARDS) market.

– To understand the future market competition in the Acute Respiratory Distress Syndrome (ARDS) market.

List of Companies:

– Faron Pharmaceuticals

– PhaseBio Pharmaceuticals

– Sage Therapeutics

– Chimerix

– Direct Biologics

– Kiniksa Pharmaceuticals

– Pluristem Therapeutics

– Alexion Pharmaceuticals

– Biomarck Pharmaceuticals

– Athersys

– Veru

– Apeptico Forschung und Entwicklung GmbH

– Alexion Pharmaceuticals

– Humanigen, Inc.

– Roche Pharma AG

– Alexion

– Mylan Laboratories

– Vanda Pharmaceuticals Inc.; the University of Illinois at Chicago

– Laboratoire français de Fractionnement et de Biotechnologies

– Ache Laboratorios Farmaceuticos

– Implicit Bioscience

– Alexion

– NeuroRx/Relief Therapeutics

– CytoDyn

– Kiniksa

– Biohaven Pharmaceutical Holding Co. Ltd.

– Kinevant Sciences GmbH/Roivant Sciences

– Iltoo Pharma

– Eli Lilly and Company

– Merck/Eli Lilly

– Apeiron Biologics

– Roche AG

– aTyr Pharma

– Algernon Pharmaceuticals

– Histocell, S.L.

– Cellenkos Inc

– Celularity Inc.; Sorrento Therapeutics Inc.; Lung Biotechnology PBC, a subsidiary of United Therapeutics Corp.

– Hospital to Academy of Military Medical Sciences/Ivy Institute of Stem Cells Co. Ltd

– Lattice Biologics Ltd.

– Meridigen Biotech

– Theravance Biopharma,

– Mesoblast Limited

– Aqualung Therapeutics Corp.

– Diffusion Pharmaceuticals Inc.; University of Virginia

– Lamellar Biomedical Ltd.

– Leading Biosciences Inc.

– Mannkind Corp.; Immix Biopharma Inc.

– Medicinova Inc.

– Bioxytran Inc.

– Mallinckrodt plc

– GEn1E Lifesciences

– ZyVersa Therapeutics

– Quark Pharmaceuticals

– Navigen pharmaceuticals

– XORTX Therapeutics

– Tiziana

– Bioaegis Therapeutics Inc.

– Caladrius Biosciences Inc.

– Cyclacel Pharmaceuticals

– Mallinckrodt /Novoteris LLC

– Noveome Biotherapeutics

– Windtree Therapeutics

– Ampio Pharmaceuticals Inc.

– Cerecor Inc.

– Predictive Biotech, of Salt Lake City, a subsidiary of Predictive Technology Group

– Pharmazz

– Noxopharm Co.

– GlaxoSmithKline

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